Popliteal pain can be caused by osteoarthritis, meniscal injuries, popliteal cysts, popliteal synovitis and other diseases, which can be treated with general, physical, pharmacologic and surgical treatments. 1. Osteoarthritis: Osteoarthritis of the knee can involve the surrounding soft tissues and can cause pain in the popliteal fossa at the back of the knee. Attention should be paid to the protection of knee joints, oral analgesic celecoxib can be taken under the guidance of the doctor, flurbiprofen gel paste can be applied externally, sodium vitrate can also be injected into the joint cavity and glucocorticoid therapy, conservative ineffective surgical treatment is needed. 2. Meniscus injury: traumatic injury to the posterior horn of the meniscus can cause pain in the popliteal fossa on the back side of the knee. Meniscus injury should be braked immediately after elevation of the knee joint, injury within 72 hours of the acute phase of cold compress treatment, injury after 72 hours can be localized hot compresses, can comply with the doctor’s instructions oral ibuprofen analgesic treatment, the serious injury requires surgical treatment. 3. Popliteal cysts: popliteal cysts and other lesions can appear in the popliteal fossa pain, but also can touch the cystic swelling. It can be treated with oral glucosamine and other drugs to nourish the articular cartilage, oral analgesic treatment with sodium loxoprofen, and surgical treatment if the discomfort is serious. 4. Popliteal bursitis: chronic inflammation of the bursa in the popliteal fossa may cause pain and swelling in the popliteal fossa. Need to reduce joint activities, reduce the synovial membrane proliferation and irritation, can be prescribed oral ibuprofen analgesic anti-inflammatory, but also in the local injection of sodium hyaluronate drug lubrication, reduce the synovial membrane stress. Popliteal fossa pain should be treated promptly, and the appropriate treatment will help to relieve the pain symptoms as soon as possible.