Selection of antibiotics for acute septic osteomyelitis needs to be effective, combination, adequate dosage, and adequate course of treatment, and antibiotics are selected according to such principles. Sensitive antibiotics are selected on the basis of blood cultures or cultures of secretions and drug sensitivity tests, and the dosing cycle is longer, lasting at least 4-7 weeks. In general, early hospitalization, through the intravenous administration of drugs, intravenous administration is more accurate, intravenous administration of 3 weeks, after treatment, the condition is more stable, many patients should be discharged. After discharge, the change to oral antibiotics, but also continue to apply 3 weeks, until the body temperature is normal, the white blood cell count, blood sedimentation, C-reactive protein are back to normal, and the symptoms and signs of significant improvement or disappearance of the later, have to need 2 weeks, to stop the drug. The course of treatment is not fixed, 4-6 weeks is in the relatively early, early diagnosis of clear treatment, through conservative treatment can be cured patients, this course of treatment is more meaningful, and is to take a more effective antibiotic treatment, more meaningful. Through drug treatment, no effect, or even aggravation of the disease, the need for surgical treatment. Osteomyelitis treatment is not just medication, but also timely surgical treatment if necessary.