Lymphoma is a malignant tumor, and most of the advanced stages of malignant tumors are more painful. The treatment of lymphoma is mainly systemic chemotherapy. After repeated chemotherapy, the body’s resistance decreases significantly, and various infections are easily combined, and patients experience fever and other discomfort, which are not easily controlled. In addition, patients with advanced lymphoma may have infiltration of blood and bone marrow and show symptoms similar to acute lymphoblastic leukemia, such as general weakness, palpitations after activity, chest tightness and other symptoms of anemia; there may also be skin and mucous membrane bleeding, nasal bleeding and other symptoms of thrombocytopenia. Some patients with advanced lymphoma can also develop skeletal damage, mainly involving the thoracic and lumbar vertebrae, manifesting as skeletal pain, bone destruction of the lumbar vertebrae or bone thoracic vertebrae, and can develop symptoms such as spinal cord, which are often more painful for patients.