Amoxicillin discontinuation usually after a week before drinking alcohol. 1. Although amoxicillin is different from cephalosporin antibiotic drugs and does not necessarily cause disulfiram-like reactions after taking the drug, it is still not recommended to drink alcohol during the drug to avoid causing gastrointestinal reactions or other side effects. Generally speaking, the metabolism cycle of the drug is 3-7 days, but in order to ensure that the drug is metabolized cleanly, the patient should try to stop the drug 7 days before drinking. 2. During the period of taking amoxicillin, attention should be paid to drink more water to promote the metabolism of the drug. 7 days after drinking alcohol should also avoid drinking too much alcohol, to avoid leading to gastric mucous membrane damage or serious damage to the liver, thus increasing the burden on the liver. Alcohol is not recommended for any medication. In case of discomfort, consult a doctor promptly.