High blood creatinine and urine erythrocytes are divided into physiologic and pathologic. Physiological includes strenuous exercise, etc. Pathological may be caused by nephritis, stones, tumors and so on. 1. Physiological: after strenuous exercise, hematuria and elevated blood creatinine may occur, which may return to normal after rest, and attention should be paid to the follow-up. 2. Pathological: Nephritis, also known as glomerulonephritis, is mainly manifested by proteinuria, hematuria, edema, hypertension, often accompanied by renal insufficiency. Patients with nephritis will have elevated blood creatinine and hematuria, reducing hematuria and lowering urinary protein is an important part of nephritis treatment, and the commonly used drugs are chlosartan, valsartan, captopril, enalapril and so on. Stones, tumors and other reasons lead to tissue destruction and erosion caused by bleeding, the formation of hematuria, high urine erythrocytes; if stones, tumors lead to urinary tract obstruction, the patient’s blood creatinine will also be elevated, the need for timely treatment. Patients with high blood creatinine and urine erythrocytes should go to the hospital in time to see a doctor, under the guidance of a professional physician to clarify the cause of the disease and timely treatment.