Which one is serious, high glomerular filtration rate or low glomerular filtration rate, mainly depends on the reasons for its increase or decrease, and cannot be generalized. 1. Decrease in glomerular filtration rate: If it is caused by acute renal insufficiency, such as diarrhea, obstruction, etc., most of the renal function can be restored to normal after correcting the reversible factors, which is usually not serious at this time; if it is caused by chronic renal insufficiency, such as chronic nephritis, diabetic nephropathy, etc., with the progress of the disease, it may develop into uremia, which is more serious at this time. 2. Elevated glomerular filtration rate: if it is caused by physiological factors such as high protein diet, pregnancy, etc., it may return to normal after changing dietary habits or the end of pregnancy, which is usually not serious; if it is caused by pathological factors such as diabetic nephropathy in the early stage of diabetic nephropathy, etc., which leads to its elevation, and when it does not get active and effective treatment, it may progress to chronic renal failure, which is more serious at this time. If the glomerular filtration rate is abnormal, it is recommended that patients go to regular hospitals in time for treatment or therapy under the guidance of doctors.