Generally high risk of folate metabolism does not lead to chromosomal abnormalities, but it may cause fetal neural tube abnormalities. Neural tube malformations are one of the most common birth defects, and folate deficiency is the leading cause of fetal neural tube malformations. When the test suggests a high risk of folic acid metabolism indicates a low utilization of folic acid, which generally does not cause fetal chromosomal abnormalities, but it is necessary to follow the doctor’s instructions to increase the dose of folic acid in order to correct the state of folic acid deficiency in the body of the pregnant woman, which can effectively prevent the occurrence of neural tube malformations. Folic acid supplementation for pregnant women should be started at least in the third trimester of pregnancy, which can prevent the occurrence of open spina bifida, anencephaly and other neural tube malformations in the fetus. For those with high risk factors such as high risk of folic acid metabolism, the dose of folic acid should be increased as prescribed by the doctor and continued until 10 to 12 weeks of gestation, after which it should be appropriately reduced and maintained until the postpartum period.