Blisters are actually blisters. Large blisters on the soles of the feet require medical attention to poke them in a sterile environment. However, blisters need to be treated according to the specific cause of the disease, and the common causes are repeated friction, fungal infection and other factors. 1. Repeated friction: ill-fitting shoes, walking for a long time and other factors will make the soles of the feet repeatedly friction, which will lead to the appearance of large blisters. Generally, the liquid inside the blisters will be gradually absorbed and no special treatment is needed. But for the blisters that affect normal life, you need to go to the doctor to poke the blisters in a sterile environment, but keep the epidermis of the blisters to avoid bacterial infection. 2. Fungal infections: Fungal infections of the feet can cause skin diseases, which can appear on the soles of the feet blisters, peeling, itching and other symptoms. Because this disease is infectious, so can not directly poke the blisters, the need for medical syringe to suck out the liquid and protect the epidermis of the blisters, so as to avoid secondary bacterial infection, aggravate the condition. It is recommended that patients with large blisters on the soles of their feet seek medical attention in a timely manner, under the guidance of a doctor to clarify the cause of the disease and standardize the diagnosis and treatment, do not pick out the blisters on their own, so as not to aggravate the condition.