The large pancreatic tumor occupied almost the middle of the abdominal cavity. The portal vein cancer thrombus continued from the edge of the tumor to the hepatic hilar region and was vast in scope. Xiao Wang, a 23-year-old girl, was found to have a solid pseudopapillary tumor in the caudal part of the pancreatic body six months ago due to abdominal bulge. Unfortunately, although pancreatic solid pseudopapillary tumor is a low-grade malignant tumor, Xiao Wang’s tumor had completely invaded the superior mesenteric vein and portal vein, and was also close to the abdominal trunk vessels, and more frighteningly, the imaging suggested that there was already a 9-cm-long cancer embolus in the portal vein, which was seriously life-threatening. The medical textbook indicates that malignant tumor combined with portal vein cancer embolism is the “anti-surgical indication”. Because the pancreas is located in the deepest part of the abdominal cavity, the field of vision is poorly exposed and surrounded by important blood vessels, it is almost an impossible task to remove the tumor and remove the cancer embolus in the “vascular plexus”. Xiao Wang was almost “sentenced to death”. After being rejected by several hospitals, Xiao Wang recently came to the Department of Pancreatic Surgery of Ruijin Hospital of Shanghai Jiaotong University. Chief physician Peng Chenghong carefully studied her images and found that the embolus in the upper segment of the portal vein was closer to a thrombus than a cancerous embolus, and that the tumor should be able to be taken down completely by removing the invading portal vein. Out of confidence in their own technology and the courage to challenge the forbidden area of life, the Ruijin pancreatic surgery team decided to operate on her based on full communication with the patient and her family. The surgery was more difficult than expected. The tumor with a size of about 8.7*6.5cm adhered to the portal vein for 3cm. Peng Chenghong led the team to carefully explore the tumor edge, patiently free the surrounding tissues until the abdominal trunk vessels and the common hepatic artery were completely naked, and the cancer thrombus in the portal vein was successfully removed to complete the portal vein reconstruction. The assistant recalled, “The whole process of nudization was more exciting and clearer than the dissection in the textbook.” During the exploration, the surgeons found another liver metastatic lesion, which was removed together. Such a large and unconventional surgery took four hours, with only 500ml of bleeding. At present, Xiao Wang is recovering well and will be discharged from the hospital in the next day.