Surgery, radiotherapy, chemotherapy and targeted therapy can be chosen according to the physical quality of the patient and the severity of the disease to improve the prognosis of rectal cancer after metastasis of peri-intestinal lymph nodes. If the disease is detected early, the lymph node metastasis is limited and the patient’s physical condition is good, the tumor lesion can be completely removed through surgical treatment. If the lymph nodes have multiple metastases, the foci are large and the patient is unable to tolerate surgery, radiotherapy and targeted therapy should be chosen under the guidance of the doctor to improve the patient’s clinical symptoms. Due to individual differences, the drugs are not absolutely effective and safe, you need to follow the doctor’s instructions to choose the chemotherapy drugs and targeted drugs suitable for you, the emergence of adverse reactions to timely consultation, drug allergy is prohibited. Therefore, it is recommended that patients relax and cooperate with doctors to receive standardized treatment to improve the quality of life and prolong the survival time of patients.