Dry syndrome patients with red rash on the face need to dry syndrome drug treatment, commonly used drugs are hydroxychloroquine, prednisone, rituximab and so on. Common symptoms of dry syndrome are parotid gland swelling and pain, dry mouth, dry eyes, etc. In addition, there will be a red rash above the skin surface, mostly in the patient’s lower limbs, which usually appears in batches and can subside on its own, so patients with dry syndrome with a red rash on the face need to be treated with drugs for dry syndrome. Commonly used medications for the treatment of dry syndrome include non-steroidal anti-inflammatory drugs such as diclofenac, anti-malarials such as hydroxychloroquine, glucocorticosteroids such as prednisone, and biologics such as rituximab, and so on, and the treatment plan should be formulated according to the specific condition of the patient. It is recommended that patients with dry syndrome who have rashes on the face should go to the rheumatology and immunology departments of regular hospitals for detailed consultation and standardized treatment according to the doctor’s instructions.