Previously, we mainly introduced the American Society of Hematology about New Crown vaccine and hematological diseases, but some details were not perfect, such as the relationship between PD-1 and other immunosuppressants and New Crown vaccine was not introduced in detail. After consulting UPTODATE, NCCN vaccine guidelines, Cancer Immunotherapy Association and recent related literature, we would like to make this popularization in order to avoid being misled by the so-called bricklayers on a certain degree. What is the relevance of PD-1 inhibitors, which are immunecheckpointinhibitors (ICI), to the new crown vaccine? The academic consensus is that the combination of the two may enhance each other’s effects, with possible enhanced side effects or no statistical difference, subject to clinical observation. However, the advantages of vaccination may outweigh the disadvantages, so uptodate, NCCN, Cancer Immunotherapy Association, etc. all consider neostriatal vaccination to be non-contraindicated during the application of PD-1 therapy. Transplantation or CAR-T with neo-crown vaccine This has been described in the previous section, refer to the post-transplantation vaccination schedule. The earliest is after 3 months of treatment. NeoCrown vaccine-associated lymph node enlargement and its impact on imaging Lymph node enlargement usually occurs within 2-4 days after vaccination and lasts for an average of 10 days. Therefore, recent (usually infection and inflammation cause lymph node enlargement lasting about 2-3 weeks, and detection after 4-6 weeks often has less impact) New Crown vaccination has an impact on imaging. Impact of New Crown vaccine on mammography screening Mammography screening should be scheduled before the first dose of vaccine or 4-6 weeks after the second dose of vaccine. Need for New Crown Vaccine in Oncology Patients The American Cancer Society’s guidelines for vaccination of cancer patients do not have an opinion on New Crown vaccination. The NCCN guidelines recommend that the New Crown vaccine can be administered. Do I need a special diet during the neostriatal vaccination? The WHO specifies that there is no evidence that diet or beverages such as alcohol have an effect on the vaccine.