Ultrasound shows that the gallbladder wall is slightly thick and rough, which can be seen in gallbladder stones, acute cholecystitis, hepatitis and other diseases. Clinical treatment according to different causes of gallbladder wall roughness, take different treatment programs. 1. Gallbladder stones: gallbladder stones can cause obstruction of the gallbladder duct, forming gallbladder mucous membrane damage, ultrasonic examination can find the gallbladder wall roughness. 2. Acute cholecystitis: gallbladder wall mucosal injury, congestion and edema, epithelial cell necrosis and detachment, may appear gallbladder wall roughness. 3. Hepatitis: patients with chronic hepatitis will have lymphatic fluid reflux obstruction and sodium retention, which can lead to gallbladder wall damage and slightly thick and rough gallbladder wall. In the physical examination found that the gallbladder wall is slightly thick and rough, we should go to the hospital in time to do the relevant examination, clear cause of the disease and active treatment. In terms of diet, you should eat more frequent meals and less high-fat food.