The differences between lumbar muscle strain and ankylosing spondylitis are different causes, different symptoms and different treatments. 1. Different causes: lumbar muscle strain is usually a chronic injury inflammation of the lumbar muscles and attachment points of fascia and periosteum, usually due to untreated lumbar sprains and overloading of the local area. Ankylosing spondylitis is usually the sacroiliac joints and spine inflammation as the main symptom of the disease, the cause of the disease is not clear, usually in the genetic factors as well as environmental factors and other aspects of the impact and lead. 2. Difference in symptoms: The symptoms of lumbar muscle strain are mainly manifested as recurring widespread lumbar pain, and some patients may be accompanied by activity difficulties. Ankylosing spondylitis is mainly located in the spine, joints, patients can manifest as low back pain, spinal ankylosis, hip, knee or ankle joint pain, with the progress of the disease, the patient can occur hunchback. 3. Different treatments: patients with lumbar muscle strain should avoid overwork, correct poor posture, but also to strengthen the lumbar back muscle exercise to prevent muscle tone disorders, follow the doctor’s instructions can also be applied to closed therapy, such as injection of lidocaine, etc. for treatment, which can alleviate the pain and reduce inflammation. Patients with ankylosing spondylitis usually need to control inflammation, and anti-inflammatory and analgesic drugs, such as ibuprofen tablets, can be used to relieve pain symptoms. Total hip replacement should be considered for hip pathology causing intractable pain or joint disability and structural damage with radiologic evidence, regardless of age. In cold weather, care should be taken to keep warm to avoid aggravation of lumbar muscle strain and ankylosing spondylitis, and symptoms should be treated promptly and according to medical advice.