Patients with gray nails experience pain when wrapping the medication, mainly due to the irritation of the skin tissue caused by the antifungal medication. Gray nails are a common fungal disease caused by fungal infection of the nail plate and the nail tissue, and can be treated with topical antifungal medications. In order to ensure that the medication reaches the lesion and has a good fungicidal effect, salicylic acid or ointment is usually used to wrap and dissolve the diseased nail. These nail dissolving drugs not only have a dissolving effect on the nail, but also have a certain corrosive effect on the surrounding skin, so there will be a painful sensation after the wrapping. Under normal circumstances, this pain usually does not last long. If the pain is more severe or lasts for a longer period of time, it should be considered that the patient is sensitive to the medication or the medication is irritating, so you need to seek medical attention immediately and stop the medication and wash thoroughly to prevent the condition from getting worse. In addition, some patients may be due to the wrapping of medical tape wrapped too tightly, resulting in poor local blood circulation, causing pain around the affected nail. In this case, patients need to seek medical attention, remove the tape and check that there is no local bruising, swelling and pain and other abnormalities before wrapping again.