LSIL medically refers to low-grade squamous intraepithelial lesions of the cervix caused by human papillomavirus infection.
LSIL is primarily a cytologic change in the squamous epithelial cells of the uterine cervix that occurs after a patient has been infected with the human papillomavirus, and requires cytologic screening for diagnosis, which reveals histologic lesions such as disorganization of the cells under the microscope, loss of polarity, upward movement of nuclear divisions from the basal lamina to the mid-surface lamina and formation of scooped out cells, as well as cytologic features such as poor keratinization and nuclear anisotropy.
Patients with LSIL may have clinical symptoms such as increased vaginal discharge and contact bleeding. Most patients with LSIL will subside naturally, but there is a certain chance that it will progress to highly squamous intraepithelial lesions or even cervical cancer. Once patients find out that they have LSIL, they should actively treat it and follow up regularly for monitoring, and should not blindly use medication on their own to avoid aggravating or delaying the condition.