PET/CT is the most sensitive non-invasive test for early diagnosis and localization of tumor lesions, and is regarded as “the crown of modern medical technology”. Unlike traditional imaging technology, PET/CT is a “functional + imaging” technology that perfectly integrates PET and CT: PET provides detailed molecular information on the function and metabolism of the lesion, while CT provides precise anatomical positioning of the lesion, and tomographic images of the whole body can be obtained in a single image, which is sensitive, accurate and specific to the overall condition of the whole body. The CT can provide precise anatomical localization of the lesion and obtain tomographic images of the whole body in all directions in one image, which can provide a sensitive, accurate and specific understanding of the overall condition of the whole body and achieve early detection of the lesion and diagnosis of the disease. The application of PET/CT is particularly important for the pancreas, which is a deep organ. A significant number of clinical early stage pancreatic cancers are detected by PET/CT, and a significant number of advanced pancreatic cancers are treated with a change in treatment strategy due to the identification of distant metastatic lesions by PET/CT. Therefore, PET/CT is an important diagnostic and treatment tool in pancreatic cancer clinical practice and scientific research. However, in the past, the application of PET/CT in pancreatic tumors has focused more on the benign and malignant diagnosis and disease staging, and less on the prognosis (survival) of pancreatic cancer patients; meanwhile, the analysis of PET/CT results has focused more on the uptake fraction of the highest metabolic uptake point (SUV value) in the tumor, ignoring the overall tumor activity. In this regard, Prof. Liu Liang’s group worked with the Department of Computer Science of Fudan University for one year to improve the application of PET/CT in pancreatic cancer: on the one hand, the group broke through the limitation of traditional imaging technology of “point to surface” and innovatively reconstructed PET/CT images in three dimensions, defining for the first time On the one hand, the group broke through the limitation of traditional imaging technology “from point to surface”, and innovatively reconstructed PET/CT images in three dimensions to define “metabolic tumor volume” and “metabolic tumor burden” for the first time. This is a comprehensive measure of the overall tumor metabolic activity or “tumor activity”. This is similar to the previous technique, which only analyzed the worst “leader” of the “bandit” group to study how bad he is, while the 3D imaging focuses on the activity of all “bad guys” in the “bandit” group. The activity of all the “bad guys” in the group of “bandits” is fully investigated after 3D imaging. Theoretically, the overall destructive power of a group of bandits is much stronger than the energy of a single bandit. Therefore, 3D imaging or overall analysis of tumor activity should be more comprehensive than focusing on the activity of the highest metabolic region. On the other hand, the group applied PET/CT overall activity values (MTV/MTB) for the first time to the analysis of postoperative survival of pancreatic cancer patients: it was found that the higher the metabolic load/volume of the overall tumor as defined by preoperative PET/CT, the shorter the postoperative survival of the 126 pancreatic cancer patients included in the study after radical resection. In other words, the more active the overall tumor, the worse the patient prognosis. This correlation is not available with the current PET/CT clinical reports with a single SUV value. This innovative technique and its conclusion can make a clearer prediction of the length of postoperative survival of pancreatic cancer patients non-invasively and preoperatively, which has great clinical translation value. This finding was accepted in full by the world’s top journal of nuclear medicine “Eur J Nucl Med Mol Imaging” in 2014, which is a rare achievement in this field especially for domestic experts in the field of surgery.