Slurred speech, or lisp, often occurs in childhood. During childhood, some children deliberately imitate other accents or are educated in the wrong way, resulting in a slurred speech, which is not an organic lesion and requires patience to correct the pronunciation, and the symptom can usually be corrected as they grow older. However, some lisp in children may be caused by organic oral lesions, such as cleft palate and short tongue ligament, which should be promptly treated with surgery in dentistry. In addition, systemic diseases can also cause developmental delays and mental retardation in children, resulting in lisp, and it is recommended to choose hospital treatment or rehabilitation in special education schools. Certain causes of adult lisp are due to untreated pronunciation problems in childhood. However, if slurred speech occurs suddenly, we should be alert to acute cerebrovascular disease, such as cerebral hemorrhage and cerebral infarction. If patients gradually develop symptoms of slurred speech, we need to investigate brain tumors, or degenerative diseases of aging, such as Parkinson’s disease, cerebellar ataxia, multiple sclerosis, and dementia, which may lead to symptoms of slurred speech, along with other symptoms, such as motor retardation, expression reduced expressions, limb tremors, etc. Patients with slurred speech should not be overly anxious, and need to maintain a relaxed and positive mood, and go to the hospital for appropriate treatment according to the doctor’s recommendations, in order to solve the problem of slurred speech as soon as possible.