Babies born with agenesis of the corpus callosum can survive, but are often accompanied by problems that cause mental retardation, hydrocephalus, and epilepsy. The main function of the corpus callosum is to connect the two hemispheres of the brain and is an important structure within the cranium. Agenesis of the corpus callosum in infants is a major cranioencephalic malformation that can have a serious impact on cranioencephalic development. Infants with agenesis of the corpus callosum often have other structural malformations of brain tissue development, such as narrowing of the cerebral aqueduct and hypoplasia of the septum pellucidum. They may survive after birth, but often suffer from mental retardation, hydrocephalus, and epilepsy. Babies with agenesis of the corpus callosum will bring a huge economic and mental burden to the family in the process of growing up, and only medication can be taken to control agenesis of the corpus callosum and associated diseases, and there is no direct way to repair the agenesis of the corpus callosum, so it is not recommended to give birth to a baby with agenesis of the corpus callosum if it is detected before birth. Pregnant women should follow the doctor’s instructions and undergo labor and delivery tests. If fetal malformations are found, it is recommended to go to a regular hospital as soon as possible for eugenic counseling and follow the doctor’s instructions for treatment.