Thoracic 12 vertebral body bone defect, after a detailed examination, to clarify the cause of the disease, and then carry out the relevant treatment. The common causes of thoracic 12 vertebral body bone defect include tumor, tuberculosis, fracture and so on. Tumor of the thoracic 12 vertebrae, resulting in vertebral bone loss, is due to the infiltration of tumor cells, which destroys the bone of the vertebrae, and usually requires surgical treatment to remove the tumor vertebrae, replace it with artificial vertebrae and fix it. Vertebral tuberculosis is caused by tubercle bacillus eroding the bone of the vertebral body, resulting in bone defects. Surgery is needed to remove the lesion and fix it with bone graft. Osteoporotic vertebral fractures in the elderly can also be caused by compression fractures that result in bone defects in the vertebral body and require cementing of the vertebral body. Specific treatment methods need to go to the hospital to improve the relevant examination, after clarifying the cause of the disease, under the guidance of the doctor for further treatment.