Shu Liver and Stomach Pill and Omeprazole can be taken together within the scope of indications and should be used in accordance with medical advice. Shu Liver and Stomach Pill is composed of Hou Pu, Xiang Fu, Qing Pi, Citron, Paeonia lactiflora, Chai Hu, Chen Pi, Sandalwood, Cardamom, Betel Nut, Yan Hu Suo and other medicines, which has the effect of inducing stagnation and harmonizing the middle, dredging the liver to open up the depression, and it can be used for the disorders of the liver and stomach (the disharmony of the liver’s ascending and the stomach’s descending functions) resulting in the chest and ribs (the chest and the rib cage area) fullness and stuffiness, gastric and epigastric distension, bloating, constipation, etc. The adverse effects of this drug are not clear, and pregnant women are contraindicated. Adverse effects of Shu Liver and Stomach Pill are not clear, and the drug is contraindicated in pregnant women. Omeprazole belongs to the proton pump inhibitor, suitable for stress ulcers, gastric ulcers, reflux esophagitis, duodenal ulcers and so on. Omeprazole adverse reactions can be seen headache, gastrointestinal flatulence, diarrhea, nausea, abdominal pain, constipation, increased aminotransferase. The drug is contraindicated in people with severe renal insufficiency and those who are allergic to the product. Shu liver and stomach pill and omeprazole instructions do not specify the existence of drug interactions, there is no contraindication, if you need to take together, should be under the guidance of a doctor to use reasonable medication, not self-medication.