Cytomegalovirus infection is a sexually transmitted disease caused by cytomegalovirus (cmv). Cytomegalovirus is a DNA virus. The characteristic lesions are enlarged infected cells with eosinophilic and basophilic inclusions in the nucleus and cytoplasm, respectively.CMV infection is distributed worldwide and humans are the only host of CMV. The rate of infection varies by country and economic status. There is a close relationship between CMV infection and immune function in adults. What are the symptoms that can be easily confused with it? The clinical manifestations of this disease vary in severity systemic giant cell inclusion body disease mainly occurs in newborns and young infants so when seen jaundice hepatosplenomegaly skin petechiae microcephaly intracranial calcification should be noted with toxoplasmosis sepsis, congenital biliary obstruction, lactational hepatitis, systemic herpes simplex, congenital leukemia, congenital rubella syndrome and so on. Jaundice is a common symptom and sign, which occurs due to an increase in the concentration of bilirubin in the serum caused by impaired bilirubin metabolism. Clinically, the sclera, mucous membranes, skin and other tissues are stained yellow. Because the sclera contains more elastin and has a stronger affinity for bilirubin, scleral yellowing is often detected before mucous membranes and skin in patients with jaundice. When total serum bilirubin is 17.1 to 34.2 μmol/L, and jaundice is not visible to the naked eye, it is called occult jaundice or subclinical jaundice. 2, intracranial calcification Calcification is one of the most common signs of intracranial calcification, and calcification is a common sign of cranial CT and MRI examination. Disorders associated with intracranial calcification include headache and intracranial low pressure headache; symptoms associated with intracranial calcification include dementia, calcification, and intracranial calcification. 3. Toxoplasmosis, also known as toxoplasmosis, is a zoonotic disease caused by Toxoplasma gondii. It is widely parasitized in the nucleated cells of humans and animals. The clinical manifestations of the disease are complex, and its symptoms and signs lack specificity, which can easily lead to misdiagnosis, mainly affecting the eyes, brain, heart, liver and lymph nodes. Toxoplasma gondii is one of the most important pathogens causing embryonic malformations during intrauterine infection during pregnancy. The disease is also closely related to AIDS. 4.Biliary obstruction Chills and fever, jaundice, pain in the right upper abdomen. White stool is associated with gallstones and cholecystitis, which are acute inflammatory diseases of the biliary system caused by bacterial infection, often accompanied by biliary obstruction. When the bile duct obstruction is more complete and the bacterial infection in the bile duct is heavy, serious clinical symptoms can occur. 5, hepatitis Hepatitis is a collective term for inflammation of the liver. It is usually caused by a variety of pathogenic factors – such as viruses, bacteria, parasites, chemical toxins, drugs, alcohol, autoimmune factors and other factors that cause damage to liver cells, the function of the liver is damaged, causing a series of uncomfortable symptoms in the body, as well as abnormal liver function indicators. 6, congenital leukemia Congenital leukemia (congenitalleukemia, CL) is a rare type of leukemia, is a leukemia diagnosed from birth to 8 weeks after birth. The etiology and pathogenesis are unclear and may be related to genetic and somatic abnormalities. It is often associated with congenital malformations, such as trisomy 21 and Turner syndrome.