Pendulum in medicine known as malaria, the treatment of this disease mainly includes quinoline derivatives, artemisinin and its derivatives, etc., but the specific efficacy are different from person to person, can not be asserted that taking which drug is better fast. 1. Quinoline derivatives: such as chloroquine, quinine, primaquine and so on. Among them, chloroquine is currently the first choice of treatment for non-drug-resistant malaria. 2. Artemisinin and its derivatives: oral preparations are mainly dihydroartemisinin. These drugs have a rapid onset of action and are often used as rescue medications for severe malaria. In addition to dihydroartemisinin, these drugs also have artesunate, artemether and other injectable forms. 3. Anti-folate drugs: such as pyrimethamine, sulfadoxine and so on. Mainly used as auxiliary and preventive drugs. 4. Nucleoprotein synthesis inhibiting drugs: such as tetracycline, clindamycin, doxycycline and so on. Mainly used in combination therapy. It should be noted that the therapeutic effects of the above drugs are still affected by the patient’s physical condition and drug compliance, the severity of the disease, other interventions and other factors, and the specific efficacy of the treatment may have individual differences. Therefore, it cannot be assumed that the use of any one drug will “get better faster”. Malaria medications are contraindicated in people who are allergic to them, and some are contraindicated in pregnant women, newborns, and patients with severe liver or kidney disease, who may experience adverse effects such as headache and nausea. To summarize, the diagnosis of malaria must be strictly under the guidance of the doctor for the use of drugs, and closely observe the efficacy of the drug and reaction, if there is not adaptive timely medical treatment. Do not blindly use the drug or increase or decrease the dosage by yourself, so as not to cause adverse consequences.