If the first and fifth of the five items of hepatitis B are positive, they are often positive for hepatitis B surface antigen and hepatitis B core antibody, which are commonly known as hepatitis B minor triplets. This result is the watershed between hepatitis B major triplets and hepatitis B minor triplets, which can be converted to either major triplets or minor triplets. If it turns out to be hepatitis B major triple-positive, it will be a good result of the period of transition to minor triple-positive through effective anti-hepatitis B virus treatment, and such a result will be produced. If the original hepatitis B is minor third-positive and it becomes a case of minor second-positive, it is the process of transformation to major third-positive. Major triple-positive hepatitis B represents a large amount of hepatitis B virus replication in the body and a high viral load. If the hepatitis B minor third-positive represents a gradual decrease or no replication of the hepatitis B virus and a relatively low viral load, it is a relatively stable state of the hepatitis B virus in the body, so the nature of the minor second-positive cannot be determined.