Facial muscle twitching or clonic facial muscle spasm refers to the painless contraction of the muscles innervated by the facial nerve. The first symptom often starts with a slight tremor of the orbicularis oculi muscle of the lower lid, and gradually extends upward to all the orbicularis oculi muscle and then to the lower half of the facial muscle, especially the corner of the mouth twitches more often. In severe cases, the whole facial muscles and the ipsilateral broad neck muscles can be spasmed, and when the orbicularis oculi muscle is severely spasmed, the eyes cannot be opened, thus affecting walking and work, and may be accompanied by mild weakness and muscle atrophy. The spasm may be aggravated by mental stress, fatigue and voluntary movement, and disappears during sleep. Facial muscle twitches are not associated with pain, and the random contraction of facial muscle is generally unaffected during non-facial muscle twitches. The etiology of facial twitches is not clear and may be caused by ectopic excitation of the facial nerve or pseudo-synaptic transmission. Occasionally, it is due to compression of the facial nerve root by an aneurysm, arteriovenous malformation, or brain tumor. Very few patients present with twitching of the affected facial muscles after trauma, tumor or surgical procedure. As for the treatment of facial muscle spasm, early treatment of facial muscle spasm can be done with medications such as oral carbamazepine, clonazepam or baclofen. In addition to Western medicine, Chinese herbal medicine can be used in conjunction with acupuncture and massage treatment. In the case of ineffective drug treatment, Botox can be used to achieve more satisfactory results. Botulinum toxin treatment is to select several injection sites for intradermal injection of the configured botulinum toxin in the upper eyelid, lower eyelid, and outer corner of the eye where muscle twitching is obvious, and the effect usually starts 3-7 days after injection. However, since the degree of facial twitching has been significantly reduced, the dose of Botulinum toxin required for treatment will be greatly reduced. The last option is nerve stem block therapy or surgical treatment, where facial nerve canal decompression is performed through open surgery. Recently, with the development of the discipline, specialists have attempted radiofrequency thermocoagulation of the branches of the facial nerve, with excellent results.