Primary liver cancer, referred to as hepatocellular liver cancer, is a common malignant tumor in China. Small hepatocellular carcinoma, also known as subclinical hepatocellular carcinoma or early hepatocellular carcinoma, has no obvious clinical signs and symptoms of hepatocellular carcinoma. Small liver cancer generally refers to hepatocellular carcinoma in which the maximum diameter of a single cancer nodule does not exceed 3 cm or the sum of the diameters of two cancer nodules does not exceed 3 cm is called small liver cancer. Early stage hepatocellular carcinoma or small hepatocellular carcinoma refers to primary hepatocellular carcinoma with tumor diameter less than 3 cm and no more than 2 tumor nodes. Patients with hepatocellular carcinoma are asymptomatic when the tumor is small, which can be called “subclinical hepatocellular carcinoma”. When patients have clinical symptoms and seek medical treatment, they are already in the middle and late stage of liver cancer. With the gradual improvement of early diagnosis level, many cases of early stage liver cancer have been discovered clinically, and sometimes some symptoms of early stage small liver cancer can be found. The common symptom is pain in liver area, which is mostly persistent hidden pain, swelling or stabbing pain, and it will be aggravated at night and after exertion. If the nature of pain of patients with liver disease changes and becomes persistent pain and gradually aggravated, and the pain does not improve after rest or treatment, we should be alerted. There are many treatment methods for small hepatocellular carcinoma, including surgical resection, ablation, TACE (percutaneous selective hepatic artery cannula infusion chemotherapy and embolization therapy), radiotherapy, bioimmunotherapy, traditional Chinese medicine treatment, etc. Radical treatment means such as surgical resection or ablation are preferred and have good prognosis.