Key Points If satisfactory repigmentation is not achieved after continued vitiligo treatment, patients may consider depigmentation to avoid skin tone contrasts. Chemical agents, such as hydroquinone and monobenzone, have been used as topical agents for such treatments, but there are increasing questions about their safety. Various types of lasers (including Q-switched, emerald and ruby lasers) are used alone or in combination with topical chemical depigmentation agents. Application of cryotherapy is expected to be effective, but there is just a possibility of repigmentation. Solution Depigmentation is an option to deal with vitiligo when all repigmentation treatments have failed, with the goal of achieving a uniform skin tone. Depigmentation is the destruction of the remaining melanocytes in the skin and patients must know that their depigmented skin tone will remain with them for the rest of their lives. Extreme photosensitivity that cannot be coped with may occur. The ideal patient for depigmentation is an adult with only a few dark patches scattered over the face and other visible areas of the body. Depigmentation is not considered for children.