Antibiotics should not be used for more than a few days can not be generalized, depending on the cause of the disease and the type of antibiotic, usually about 7 to 14 days. Anti-infective treatment for tuberculosis, non-tuberculosis mycobacteriosis, brucellosis, etc., may take months or even longer 1. Quinolone antibiotics: e.g. Norfloxacin, Levofloxacin, etc. Since this type of drug is well tolerated, it can be used for a long time, e.g. the course of Norfloxacin for prostatitis is 28 days. The drug may cause nausea, vomiting, headache, rash and other adverse reactions. 2. Macrolide antibiotics: commonly used are azithromycin, roxithromycin, erythromycin, etc. The general course of treatment for this type of drug is 5 to 12 days. The main adverse reactions caused by these antibiotics include nausea, vomiting, abdominal pain, abdominal distension and other gastrointestinal symptoms, as well as hepatotoxicity. They must be contraindicated in people who are allergic to these drugs. 3. Aminoglycoside antibiotics: representative drugs include streptomycin, gentamicin, tobramycin, kanamycin, etc. The general course of treatment is 7~14 days. The main adverse reactions of aminoglycoside antibiotics are ototoxicity and nephrotoxicity. If dysfunction occurs after using the drug, the drug must be stopped immediately. 4. β-lactam antibiotics: such as penicillin sodium, piperacillin, amoxicillin, etc., this type of antibiotic safety is relatively high, and the duration of the drug is generally 7~10 days. Common adverse reactions are diarrhea, nausea, rash. People who are allergic to the drug need to be prohibited, and skin tests need to be done before using the drug. Individuals should not abuse antibiotics, medication should follow the doctor’s instructions, can not stop the drug.