If the toothache is caused by fire, you can take drugs to reduce fire, such as the often used Niuhuang Detoxification Pill, Sanhuang Tablet, Huanglian Shangqing Pill, Jin Yinhua Granules, etc., which have good effects. If the toothache is caused by inflammation in the mouth, such as periodontitis, pulpitis, gingivitis, etc., you need to take antibiotic drugs, commonly used drugs are amoxicillin, roxithromycin, metronidazole, etc. If taking anti-inflammatory drugs and fire-reducing drugs alone do not have too obvious effect, you can take pain-relieving drugs such as ibuprofen at the same time. If the toothache does not work for about 2-3 days, you need to go to the hospital in time.