The life expectancy of patients with cirrhosis and splenomegaly is not generalizable, and the exact survival time is related to the patient’s physical condition, treatment modalities, and the presence of comorbidities. Generally speaking, the earlier the disease is detected, diagnosed and treated, the less the disease will affect the life expectancy. Generally speaking, if a patient has only simple splenomegaly on top of cirrhosis, the condition has not yet reached a life-threatening level, and his/her life expectancy can be comparable to that of a normal person if he/she receives treatment as early as possible. If there is splenomegaly on the basis of cirrhosis, body circulation stagnation, which can lead to upper gastrointestinal bleeding and ascites symptoms, suggesting that cirrhosis is in the stage of decompensation, if early treatment, its five-year survival rate can reach more than 25%. In conclusion, after the diagnosis of cirrhosis splenomegaly, patients should go to regular hospitals in time, and receive regular scientific treatment under the guidance of doctors, so as to prolong the life of patients as much as possible, and the specific survival time can also be evaluated by professional doctors.