Premature ovarian failure is a phenomenon that occurs in women after pubertal development if amenorrhea, ovarian atrophy, low estrogen levels in the body and high gonadotropin levels up to menopausal levels occur before the age of 40. The etiology of premature ovarian failure is unknown in the majority of patients. It is thought to be related to genetics, autoimmune processes, and infections. The most research has been done on premature ovarian failure and autoimmunity. In normal women, ovarian function begins to decline only at the age of 45 to 50 years; if signs of decline appear before the age of 40, it is medically called premature ovarian failure. Such women are often associated with amenorrhea or oligomenorrhea, increased gonadotropin levels and decreased estrogen levels, and clinical manifestations include varying degrees of hot flashes and sweating, vaginal dryness, decreased libido and other pre- and post-menopausal symptoms. Premature ovarian failure is divided into the following three categories: 1. Plasma ovarian premature failure: accounts for about 25% of premature ovarian failure and is common in patients aged 30 to 40. Unilateral is more common. The appearance is grayish white, smooth surface, mostly unicompartmental, with a thin cyst wall and a yellowish, clear, transparent liquid inside the cyst. In some cases, papillary protrusions are visible on the inner wall, clustered in groups or diffusely scattered, called papillary plasmacytotic cystic glands. The papillae may protrude from the cyst wall, spread and grow on the surface of the cyst, and even invade the adjacent organs. If accompanied by ascites, malignancy has mostly occurred. 2, mucinous premature ovarian failure: about 15-25% of premature ovarian failure, most common in 30-50 years old. Most of them are unilateral. The surface of the tumor is smooth, orchid-white, and multi-housed. The cyst contains coumarin-like mucus, and occasionally there are papillary protrusions in the cyst wall, which is called papillary mucinous cystic gland. 3, Premature ovarian failure: also known as cystic premature ovarian failure or dermatomal cysts. It accounts for about 10-20% of premature ovarian failure. Most of them occur in the reproductive age.