Vitiligo’s cause is complex, generally rarely spontaneous repigmentation, need to take targeted treatment according to the specific line of circumstances. The cause of vitiligo is unknown, and its occurrence may be related to heredity, trauma, mental stress, autoimmune diseases and so on. Generally rarely spontaneous repigmentation, the emergence of the disease is recommended to actively treat. For vitiligo in the stable stage can be treated by irradiation 308 excimer light, topical glucocorticoid such as halomethasone cream, topical calmodulin phosphatase inhibitor such as tacrolimus ointment, skin grafting and so on. But for the active stage of rapid development of vitiligo on the basis of the above treatment should be combined with oral glucocorticoid therapy to stop the disease development process. It is recommended that vitiligo should be treated under the guidance of a physician.