Syphilis according to the course of the disease can be divided into the first stage of syphilis, second stage syphilis, third stage syphilis, the symptoms of the performance of the existence of differences, can not be generalized. 1. Stage 1 syphilis: (1) Hard chancre: initially a red blotchy rash that rapidly turns into a papule and quickly breaks down to form an erosion or shallow ulcer. (2) Swollen inguinal lymph nodes: inguinal lymph nodes are often enlarged 1 to 2 weeks after the appearance of the chancre. 2. Second-stage syphilis: (1) Syphilis rash: red or reddish-brown papules, macules, nodules, pustules or ulcers, etc. It does not itch or itches slightly. (2) Flat warts: pink flat papules or plaques, with surface erosion or mild crusting. (3) Syphilitic alopecia: round or oval alopecia on the head in the form of worm-eaten hair, the border of the alopecia area is not clear. 3. Third-stage syphilis: (1) Skin damage: the number of skin damage is small, destructive, asymmetric distribution, and often leaves atrophic scar after healing. (2) mucosal damage: the lesions are nodular gummosis, single or multiple, located in the submucosal tissue or deeper, causing perforation of the hard palate, nasal deformation. (3) Bone damage: proliferative damage involving bones, joints and muscle tendon sheaths, manifested as bone and joint pain, aggravated at night, with a slow course. Syphilis patients should choose to seek medical treatment as early as possible to avoid aggravation of the condition.