Chronic renal insufficiency is not exactly uremia, but a decline in kidney function for more than 3 months due to various reasons is called chronic renal insufficiency, clinically chronic renal insufficiency is divided into four stages: first, the compensatory stage of renal insufficiency, blood creatinine below 178μmol/L, GFR in 60-89mL/min, no clinical symptoms; second, the decompensated stage of renal insufficiency is also called azotemia, blood creatinine in 178-442μmol/L, GFR in 30-59mL/min. There are symptoms but not obvious, nocturia or polyuria, mild anemia, weakness, loss of appetite; Third, renal failure stage, blood creatinine is 442-707μmol/L, GFR is 15-29mL/min, renal function is seriously impaired, there are obvious anemia, nausea, vomiting, acidosis The symptoms are: anemia, nausea, vomiting, acidosis, hypertension, hypocalcemia, hypocalcemia, hypophosphorus, hyperkalemia, and even coma. Hyperparathyroidism.