To determine the treatment of high anti-thyroglobulin antibodies requires further examination, first of all, to improve the thyroid function, if the thyroid function is normal, usually can be temporarily observed without special treatment; if the thyroid function is abnormal, then further examination is needed to confirm the diagnosis of the disease, and then carry out the appropriate medication, radiotherapy or surgical treatment. 1. If the anti-thyroglobulin antibody is elevated, the thyroid ultrasound does not show any obvious abnormality, and the thyroid function is normal, then there is usually no need for special treatment for the time being, and regular monitoring of the thyroid function and thyroid ultrasound will be sufficient. 2. The need for treatment: ① If the thyroid function suggests hypothyroidism, it is necessary to follow the doctor’s advice to take levothyroxine sodium tablets to replace the treatment. If thyroid function suggests hyperthyroidism, you need to take antithyroid drugs, radioactive iodine therapy or surgical treatment. In conclusion, high anti-thyroglobulin antibodies need to go to the endocrinology department for further consultation, improve the thyroid function, thyroid ultrasound and other definitive diagnosis to determine the treatment plan.