There are side effects associated with the use of PD-1 inhibitors in lung cancer, including systemic adverse reactions, endocrine and metabolic adverse reactions, infectious diseases, and connective tissue adverse reactions. 1. Systemic adverse reactions: anemia, abnormal body temperature, fatigue and weakness, abnormal weight change may occur. 2. Endocrine and metabolic adverse reactions: abnormal thyroid function, abnormal lipid levels, abnormal uric acid metabolism, etc. may occur. 3. Respiratory system adverse reactions: pneumonia, bronchial and other upper respiratory tract infections may occur. 4. Adverse reactions of connective tissue: muscle pain, rash, skin itching and other manifestations may occur. 5. Adverse reactions of the digestive system: diarrhea, hepatitis, dyspepsia and other manifestations may occur. Adverse reactions are serious and need to stop using the drug. It should be noted that any drug has different degrees of adverse reactions, the use of drugs need to be carefully evaluated by a physician. Do not resist treatment because of fear of adverse reactions.