Cirrhosis of the liver may cause generalized numbness. Cirrhosis may be associated with viral hepatitis, alcoholic hepatitis, steatohepatitis and other diseases. There may be symptoms such as loss of appetite, bloating, nausea, diarrhea, ascites, and coagulation disorders. Cirrhosis when liver cells lose normal form, pseudo lobar and regenerative nodule formation leads to decreased liver detoxification function, may lead to accumulation of toxins to stimulate the nerves to appear generalized numbness; Cirrhosis generalized numbness may also be related to low nutritional intake, vitamin deficiency caused by peripheral neuropathy and other reasons. Cirrhosis generalized numbness may also be related to cirrhosis combined with cervical spine, insufficient cerebral blood supply, cerebral infarction and other diseases, so it is necessary to further check liver function, cranial CT, cervical spine CT, electromyography and other items to find the cause.