According to patient’s condition, the pain of bone cancer can be relieved by two aspects: anti-tumor treatment and analgesic treatment. Anti-tumor therapy: according to the pathological type and clinical stage of bone cancer, surgery, chemotherapy, radiotherapy, immunotherapy, intervention therapy and other methods can be chosen to kill the tumor cells so as to relieve the symptoms. Analgesic treatment: the use of analgesic drugs is mainly based on the different degrees of pain, and different steps of analgesic drugs are chosen, such as indomethacin and acetaminophen in the first step, codeine and tramadol in the second step, and morphine and oxycodone extended-release tablets in the third step. In addition, bisphosphonate drugs such as zoledronic acid reduce the bone destruction of bone cancer to relieve pain. The above treatments should be carried out under the guidance of doctors. It is recommended that patients go to regular hospitals to avoid delaying their condition.