A review of the relevant literature published in Endocrine reviews 2014 Mar 27 ; er20131051 found that excessive light exposure at night disrupts the biological clock, leading to weight gain. A variety of genes and hormones involved in nutrient metabolism are known to affect the biological clock, and results from animal experiments show that mice with mutations in biological clock genes have changes in feeding behavior, endocrine signaling, and dietary fat absorption. Light exposure at night alters the timing of feeding in mice. Fonken believes that these results are important for humans because people often use computers late at night and even leave the lights on at night. Street lights will also enter the house through the window. These light sources may all affect the biological clock and thus interfere with the normal metabolism of the body. Epidemiological studies have shown that shift workers are more prone to obesity, hypertension and hypertriglyceridemia. Night shift workers exposed to light for longer periods of time are at increased risk of developing cancer as well as sleep disorders, mood disorders, metabolic disorders and cognitive decline. Researchers have analyzed that light at night can lead to weight gain by disrupting the biological clock, disrupting cortisol and melatonin signaling pathways and affecting normal sleep. Therefore, it is important to increase awareness and attention to the circadian biological clock and the consequences of nighttime light exposure, minimize the duration of nighttime light exposure, and maintain a regular sleep schedule. According to Eve Van Cauter, a spokesperson for the Endocrine Society and professor at the University of Chicago, the review is “interesting and novel” and suggests that excessive nighttime light exposure should be considered as a new environmental risk factor for the obesity and diabetes epidemic. Even if not included in the guidelines, clinicians should routinely ask patients about their nighttime light exposure and offer ways to reduce it, which is simple and meaningful.