Lupus nephritis stage IV is possible to have children, if it is a male patient, the gonadal suppression by medication is relatively small, you can prepare for pregnancy and childbirth after six months of discontinuing immunosuppressive drugs. If you are a female patient, the effect will be slightly greater, you need to stop the relevant immunosuppressive drugs for more than half a year after the disease is stabilized before pregnancy. Because immune dysfunction may occur during pregnancy and lupus may recur or worsen, you can choose drugs that have less impact on the kidneys, gonads and fetus, such as azathioprine as an immunosuppressive drug. However, immunosuppressive drugs such as primaquine, morte-macrolide, cyclophosphamide, and leflunomide should not be used because of the high incidence of malformations in the child after the application of these drugs. After pregnancy, pregnancy must be monitored by rheumatologists, nephrologists, and obstetricians and gynecologists, and urine routine, blood pressure, urine protein quantification, and creatinine and urea should be reviewed regularly to assess the kidney and fetal growth and development of the fetus.