Uremia is the advanced stage of acute and chronic renal failure, at this time the patient’s kidneys can not be timely excess water, electrolytes and a variety of metabolites out of the body, resulting in uremia is very many reasons, generally including kidney disease, hypertension, diabetes and other factors. 1. Kidney diseases: such as chronic nephritis, glomerulonephritis and lupus kidney, etc., may cause chronic renal failure, and then may cause uremia. 2. Diabetes mellitus: it can lead to glomerular damage and cause diabetic nephropathy, which is one of the more common causes of secondary renal damage in the clinic, and it can lead to serious impact on the permeability of glomerular basement membrane, and then it loses the ability to expel water and toxins, and then it causes uremia. 3. Hypertension: Hypertension can lead to hypertensive nephropathy and renal artery stenosis, which may lead to uremia. 4. Other factors: such as toxic factors or drug factors, may also lead to kidney damage, and then the lack of effective treatment will cause uremia. If uremia occurs, you should consult the doctor in time and take active treatment under the guidance of the doctor.