If the Down’s syndrome test does not pass, the next step is mainly based on what is reported such as whether it is high risk, critical risk, or an abnormality in one of the indicators, and so on. 1. If the Down’s syndrome test indicates a high risk: If the Down’s syndrome test indicates a high risk, then the next step is to take a confirmatory approach, i.e. amniocentesis, to confirm the diagnosis before proceeding accordingly, and if necessary, consider terminating the pregnancy. 2. If the Down’s syndrome test suggests that there is a critical risk: in this case, since it is a critical risk, the risk value is not particularly high, so the next step is to carry out non-invasive DNA testing to determine whether there is a chromosomal abnormality and then deal with it. If there is no abnormality, regular observation is enough, if there is abnormality, the pregnancy should be terminated. 3. If the Down’s syndrome test suggests that one of the indicators is abnormal: in this case, the fetus is generally not a problem, and it is recommended to conduct screening through systematic ultrasound and non-invasive DNA. If there is no abnormality, the pregnant woman can also take the method of observation to deal with. Once the Down’s syndrome screening failed, it does not necessarily mean that the fetus has problems, pregnant women should not be too anxious, should be under the guidance of the doctor to improve the relevant examination, to take targeted treatment.