The stiffness of the hand can’t hold a fist tightly, considering with rheumatoid arthritis, tenosynovitis, osteoarthritis and so on. 1. Rheumatoid arthritis: usually manifested as symmetrical swelling of the joints, pain, limited activity, morning stiffness, through the rheumatism test can be a clear diagnosis, you can take oral anti-rheumatic drugs, such as pau d’arco. 2. Tenosynovitis: due to the thickening of tendon sheath caused by chronic strain injury, there are symptoms of unfavorable finger flexion and extension activities, morning stiffness, and rattling of flexion and extension joints, and tendon sheath release surgery can be performed. 3. Osteoarthritis: degeneration of finger joints, hyperplasia, narrowing of the joint space can appear stiff fingers, can’t hold a fist, by taking X-ray film to make a clear diagnosis, you can apply nutritive cartilage medication, such as glucosamine sulfate capsules. The cause of the stiffness of the hand can not hold a fist is complex, it is recommended to go to the hospital in a timely manner to clarify the cause of the disease, under the guidance of the doctor for treatment.