There are four main possibilities for pain on both sides of the breast: first, physiological pain, common in women during development or pregnancy, due to estrogen increase caused by breast congestion, edema, and accompanied by swelling and discomfort. Second, cystic hyperplasia of the breast, mostly seen in women aged 30-50 years old, the clinical manifestation is breast swelling and pain, accompanied by the formation of breast hyperplasia nodules, the pain is mostly swelling or stabbing pain, and the degree of pain is related to the menstrual cycle. Third, acute mastitis, common in lactating women, often combined with milk stagnation, clinical manifestations are breast swelling and pain and combined with fluctuating lumps. When the disease progresses to advanced stage, breast pain may appear and may be accompanied by nipple invagination or orange peel sign. When breast pain occurs, breast ultrasound or fine needle aspiration biopsy should be performed in time to clarify the diagnosis and provide reasonable treatment under the guidance of professional physicians.