HFMD is an infectious disease caused by enterovirus. There are more than 20 types of enterovirus that cause HFMD, among which Coxsackievirus A16 (Cox A16) and enterovirus 71 (EV 71) are the most common. Most children under the age of 5 years old present with mouth pain, anorexia, low fever, small herpes or ulcers on the hands, feet and mouth. Individual children with severe disease develop rapidly, leading to death. There is a lack of effective treatment drugs and the main symptomatic treatment. How to prevent hand, foot and mouth disease? Parents and caregivers should pay attention to personal hygiene and wash their hands with soap and hand sanitizer at all times when they are caring for children. 2, pay attention to children’s diet and hygiene do not let children drink raw water, eat raw and cold unclean food. Wash and disinfect the tableware used by children before use, wash and clean the toys before use, maintain a hygienic home environment, frequent indoor ventilation, and wash and change clothes regularly. 3. Do not take children to places where people gather and air circulation is poor, and avoid contact with sick children. 4.Children with fever, mild upper sensory symptoms, especially maculopapular rash or herpes in the mouth, hands, feet, anus and other places should go to a specialist clinic in time to achieve early prevention, early diagnosis and early treatment.