The common causes of calf soreness in the middle of the night are overwork, lumbar spine disease, vascular disease and other reasons. 1. Overexertion: If you are overworked during the day, it may cause calf soreness and difficulty in sleeping, which can be relieved by resting under normal circumstances. 2. Lumbar spine disease: Lumbar disc herniation, lumbar spinal stenosis and other diseases may compress the nerves innervating the calf, causing calf pain. You can use massage, physical therapy and other ways to ease the pain, if the pain is severe can be under the guidance of the doctor to take non-steroidal anti-inflammatory analgesics, such as celecoxib, ibuprofen and so on. If the pain is severe or combined with the cauda equina compression, surgery is needed. 3. Vascular disease: arterial stenosis, venous thrombosis and other conditions may also cause calf pain, can be under the guidance of the doctor to take antiplatelet aggregation drugs such as aspirin, clopidogrel, etc. for treatment, if the condition is serious need for surgical treatment. Sore calves in the middle of the night, difficult to sleep may also be caused by other reasons, the symptoms continue to be unable to relieve or severe pain, you should go to the hospital in a timely manner to find out the cause and under the guidance of the doctor for treatment.