Treatment of liver cancer with portal vein thrombus includes selective hepatic artery chemoembolization, portal vein chemoinfusion, local radiotherapy particle implantation for portal vein thrombus, portal vein stenting, etc. The specific optimal treatment plan depends on the characteristics of the patient’s tumor. 1. Selective hepatic artery chemoembolization: it is the most traditional interventional therapy, mainly because the blood supply of portal vein thrombus mainly comes from hepatic artery, and embolization of hepatic artery can cut off the blood supply of thrombus and kill the cancerous tissue. 2. Portal vein chemotherapy infusion: through direct puncture to the portal vein through the liver, chemotherapy drugs can be infused into the diseased area for treatment, which is conducive to controlling the progression of cancer thrombus. 3. Localized radiotherapy particle implantation for portal vein thrombus: implantation of radioactive particles in the thrombus of portal vein through puncture to the portal vein, so as to treat the thrombus with close-distance radiation. 4. Portal vein stenting: it can help to ensure the blood supply of the liver and reduce gastrointestinal bleeding. 5. Targeted therapy: at present, targeted therapy drugs have been widely used in the treatment of advanced liver cancer, including Sorafenib, Lenvatinib and so on. 6. Surgical treatment: for patients who are more effective in the first five treatment options, surgical treatment is also feasible, including hemihepatectomy, liver transplantation and so on. If you are suffering from liver cancer with portal vein thrombosis, you should seek medical treatment in time. Which option is the best should depend on the patient’s symptoms and tumor condition.