Pain at the knee joint may be caused by trauma, allergic reaction factors, degenerative joint changes, etc., and can be treated with medication or surgery. 1. Trauma: the knee joint is over-extended and twisted due to external impact, resulting in articular cartilage damage, dislocation or fracture, oozing of tissue fluid, swelling of the knee joint and resulting in pain, and conservative treatment or surgical treatment should be chosen according to the degree of fracture. 2. Metabolic factors: such as rheumatoid arthritis, such as diclofenac sodium and other non-steroidal anti-inflammatory drugs for pain relief, methotrexate and other immunosuppressants, such as prednisone and other hormonal drugs, may cause gastrointestinal discomfort, headache, skin rashes, etc., allergy is prohibited, and the serious need for surgical treatment. 3. Degenerative joint changes: you can choose such as Loxoprofen sodium and other non-steroidal anti-inflammatory drugs pain treatment, may cause gastrointestinal discomfort, blurred vision, dizziness, etc., allergies, pregnant women and breastfeeding women are prohibited, and serious cases need surgical treatment. Patients should pay attention to rest and avoid weight bearing on the knee joint. If there is pain in the knee joints, it is recommended that patients go to the rheumatology and immunology department of regular hospitals, orthopedics and other related departments in a timely manner, under the guidance of the doctor to standardize the treatment, and the medication should be used in accordance with the doctor’s instructions.