Mouth asymmetry should be treated promptly in order to identify the cause and standardize the treatment. This may be due to facial nerve damage, malocclusion, etc. Treatment mainly includes medication, physical therapy, surgery, etc. Mouth asymmetry can be caused by facial nerve damage. A variety of causes can lead to facial nerve damage, and the most common causes include facial neuritis and cerebrovascular disease. The most common causes include facial neuritis and cerebrovascular disease. Other causes include brain tumors and traumatic brain injury. Mouth asymmetry due to facial neuritis can be treated with methylcobalamin, glucocorticoids to reduce nerve edema and physical therapy. Mouth asymmetry caused by cerebral infarction can be treated with aspirin and other drugs to fight platelet aggregation, and flunarizine and other drugs to improve circulation. Brain tumors and traumatic brain injury can lead to surgical treatment of mouth asymmetry. Malformation of teeth may also cause mouth asymmetry, patients can go to the dentist for orthodontic treatment, after correction of mouth asymmetry symptoms can be relieved. When mouth asymmetry occurs, it is recommended that the patient go to the hospital in time to consult a professional physician to determine the condition, clarify the cause of the disease, and guide the diagnosis and treatment. Drugs should be used under the guidance of a doctor.