High glutamyltransferase may be physiologically elevated (e.g., after staying up late, drinking a lot of alcohol), or it may be caused by diseases such as viral hepatitis, bile duct stones, alcoholic liver disease, fatty liver, or immune system disorders. The causes of different medications are also different, as follows. 1. Physiological elevation: such as staying up late, drinking a lot of alcohol can occur after glutamyl transferase is high, usually in the adjustment of work and rest and improve the habits of life can be improved on their own, generally do not need to take medication. 2. Viral hepatitis: Generally, after liver function abnormalities, we need to improve the hepatitis virus test, if viral hepatitis leads to elevated glutamyltransferase, it will be treated with antiviral therapy (e.g., patients with hepatitis B can take entecavir orally to fight against the virus), and then the value of glutamyltransferase will be decreased in most of the cases. 3. Choledocholithiasis: If choledocholithiasis is the cause of glutamyltransferase elevation, it can be treated with ursodeoxycholic acid or surgery under the guidance of a physician. 4. Alcoholic liver disease or fatty liver: Liver function can be improved by adjusting the diet, quitting smoking and drinking, and exercising moderately. Oral glutathione can be taken to reduce glutamyl transferase. It should be reminded that for patients with high glutamyltransferase, it is recommended to go to the hospital in a timely manner, to clarify the cause of the disease and then targeted treatment, the drug should be taken under the guidance of the doctor.